376 papers
This study demonstrates that tethering chromatin to the nuclear envelope via the LINC complex counteracts its self-attraction to prevent excessive clustering, thereby enhancing RNAPII accessibility and promoting asymmetric chromatin organization essential for efficient transcription.
A 2025 community-based surveillance initiative in Galveston County, Texas, successfully detected and characterized highly pathogenic avian influenza H5N1 (clade 2.3.4.4b, genotype D1.1) in 70% of reported deceased birds through cross-sectoral collaboration, enabling rapid response and preventing human infections.
A 2.5-year mesocosm experiment across eight coral species reveals that symbiont community responses to future ocean conditions exist on a continuum ranging from deterministic, thermally adaptive shifts to stochastic dysbiosis, depending on the intensity of heat stress and coral lineage.
This study reveals that limb immobilization triggers a skeletal muscle-sympathetic nerve-intestine network where sympathetic activation of intestinal macrophages via 2-adrenergic receptors drives gut inflammation and the release of CXCL10, ultimately causing skeletal muscle inflammation and atrophy.
This study reveals that aging induces ferroptosis in luminal round spermatids due to lipid peroxidation, leading to a Y-chromosome bias in sperm that can be reversed by modulating redox stress with vitamin E.
This study reveals that the RNA modification pseudouridine acts as a critical biochemical code that directs specific RNAs for extracellular transport by recruiting the binding protein MYL6, a mechanism identified through genome-wide screening in neuronal models.
This study identifies the E3 ubiquitin ligase ITCH as a critical host factor that promotes SARS-CoV-2 replication and virion release by enhancing viral protein ubiquitination and assembly, facilitating autophagosome-dependent secretion, and suppressing protease-mediated spike protein destabilization, thereby highlighting ITCH as a promising therapeutic target.
This study reveals that ATP-competitive kinase inhibitors frequently trigger paradoxical, non-catalytic effects by inducing structural rearrangements in autoinhibitory domains that alter protein-protein interactions and subcellular localization, a phenomenon identified through a multimodal proteomics approach.
This study demonstrates that ancient RNA virus genomes, including near-complete sequences of picornaviruses and rotaviruses, can be successfully recovered from Adelie penguin mummies in Antarctica dating back up to 2,000 years, thereby enabling direct long-term evolutionary analysis of these viruses.
This study integrates cryo-EM, NMR, and MD simulations to elucidate the high-affinity binding mechanism of scorpion toxin CTX to the MthK channel, revealing how an anchoring lysine residue stabilizes the complex while dynamic interactions allow for broad subtype specificity.
The paper introduces PICO, a reference-free, single-vesicle profiling assay that utilizes DNA-barcoded antibodies and digital PCR to achieve high-specificity, multiplex quantification of small extracellular vesicles in liquid biopsies with minimal sample input and standard instrumentation.
This study reveals that the glucocorticoid-responsive demethylase ALKBH5 promotes hepatic gluconeogenesis and type 2 diabetes by stabilizing Ogt mRNA through m6A demethylation, identifying ALKBH5 as a promising therapeutic target for the disease.
The authors introduce tRIBO-seq, a nanopore-based method that simultaneously profiles the abundance, modifications, and fragmentation of ribosome-associated tRNAs, revealing that distinct stressors elicit unique and specific alterations in the actively translating tRNA landscape that are often undetectable in total tRNA pools.
This study elucidates the structural and biochemical mechanism of human tRNA 3'CCA maturation by revealing how the enzyme TRNT1, in complex with its mitochondrial platform, utilizes a continuous polymerization and translocation process to accommodate diverse tRNA substrates, while also providing molecular insights into disease-associated variants.
This study reveals that Lenacapavir prevents infectious HIV-1 production by inducing a "premature" capsid lattice during viral assembly that mimics the mature state despite lacking inositol hexakisphosphate, thereby disrupting the normal formation of infectious virions.
This study reveals that RNA G-quadruplexes facilitate cooperative binding of the splicing regulator HNRNPH by unfolding to expose multiple binding sites, thereby enabling switch-like regulation of hundreds of exons that is clinically relevant to breast cancer subtypes.
This study demonstrates that the NanoMosaic Tessie nanoneedle platform enables rapid, quantitative detection of specific genome truncation hotspots and particle heterogeneity in AAV9 vectors, offering a superior alternative to conventional assays for ensuring high-quality gene therapy manufacturing.
This study utilizes SEC-SAXS to reveal that G3BP1 undergoes a pH-dependent conformational switch from an elongated dimer to a compact state driven by its RGG region, which is essential for triggering stress granule assembly via liquid-liquid phase separation.
This study employs structure-based drug design to develop high-affinity ligands that induce distinct conformational states of the E3 ligase GID4, providing a foundation for future optimization of PROTACs and molecular glues to expand targeted protein degradation beyond current CRBN and VHL limitations.
This study reveals that *Pittosporum tobira* secretes extracellular single-stranded DNA (eci-DNA) from its leaf cuticle, which exerts a potent insecticidal effect against the sap-feeding pest *Coccus hesperidum* and offers a natural model for sustainable pest control strategies like genetic zipper technology.